A legacy of leading the way in pediatric drug development

“The conferees note particularly the excellent efforts of NIH, especially through the PPRU Network, which will contribute significantly to this effort.”

- CONFERENCE REPORT ON S. 830, FOOD AND DRUG ADMINISTRATION MODERNIZATION ACT OF 1997 (HOUSE OF REPRESENTATIVES - NOVEMBER 09, 1997)

The Pediatric Pharmacology Research Units (PPRU) Network, was an organization of university based pediatric clinical pharmacologists founded in 1994 by National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health. The initial funding cycle was dedicated to performing pediatric labeling studies for industry.

Over the 2 subsequent funding cycles, the PPRU became a group of multidisciplinary investigators organized around competencies to facilitate design and conduct nationally-based, multisite translational and clinical studies in pediatric therapeutics. Through the 3 funding cycles and 16 years, the PPRU attained impressive achievements in part by labeling for the pediatric population and developing translational research.

A Major Network Asset

The collective thinking and collaboration among pediatric investigators from many backgrounds:

  • Fostered transition from single-site oriented investigations to organized investigative teams from multiple sites
  • Allowed teams to work outside of institutional boundaries
  • Encouraged teams to address therapeutic issues driven by unique individual patient response to drugs  

The PPRU Network formed multidisciplinary teams of clinical pharmacologists and investigators with expertise in developmental biology, systems biology, bioinformatics, pharmacogenomics, metabolomics, and biomarker development. Emphasis was placed on fostering the integration of the knowledge gained from genomic research into developmental pharmacology.

Over the years the PPRU Network assumed a leadership role in setting the agenda for pediatric therapeutic research for the next decade. It has laid the groundwork for continued pediatric clinical trials, pediatric clinical pharmacology and therapeutics research.

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Network created common data elements and forms, study management tools, and data management tips

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PPRU funded sites across the United States, from 1994 - 2010